Wow sometimes my computer lets me on to Any DVD but I get this most of the time. SetupAnyDVD6100.exe has encountered a problem and needs to close. We are sorry for the inconvenience. I look at the data the error report contains and it says. Error signature AppName: setupanydvd6100.exe AppVer:0.0.0.0
Download and install the most recent version which I think is 6.1.2.5. If that doesn't solve the problrm, try uninstalling AnyDVD with the uninstaller located in the AnyDVD folder: Slysoft > AnyDVD > uninstall Slysoft also has a forum at their site where problems can be addressed.