Help to play game installed on "D" Drive instead of "C"

Hi, When I built my new gaming desktop I decided to only have a small "C" drive of 30 gig for the OS and some common essential programs and install anything else (such as games) onto "D" drive which is another partition on the same HDD.
I have been playing Bioshock recently but had to re-install my OS. (i have an image of the "C" drive backed-up which only takes 15 mins to get back to square one).
Trouble is, obviously the OS does not know of my Bioshock install on "D".
How do I easily play Bioshock again, from where I left off.
I realise I could just save the "game save" file(s) and replace them after a fresh install from the CD-ROM, but what about just using the Bioshock.EXE file thats already in "D" drive. Will that solve the problem.
Note that after I installed Bioshock originally, I replaced the .exe file with a "NoCD" one. This was because I could leave the CD in the Box and because I read that I could avoid the Securom shite being loaded onto my machine that way.