I have the Simply and it is very easy to use. Format the MicroSD card, make a ROMs folder for organization, put your roms into the ROMs folder, put the MicroSD card into your Simply and your Simply into the DS, and start it up. That's all you need. Homebrew isn't as readily avaiable as for the M3 Lite but it is way cheaper so I don't mind.
Same. R4DS or M3 simply. Whichever's cheaper, they're the same otherwise. The R4DS still comes with prettier packaging, a default white case, an optional black case and a keychain holder to hold 2 slot-1 carts. They both have the USB adapter to allow you to drag+drop files onto your microSD card. R4DS fanboi (They're the same thing really)